From Biology to Impact

Overview
Radiation biology has traditionally focused on understanding tumour response. Our research extends this mission by ensuring that biological discoveries shape how radiotherapy is designed, delivered and implemented. We translate fundamental biology into clinical decision-making through multidisciplinary collaborations spanning radiation oncology, medical physics, artificial intelligence, health economics and the social sciences. By integrating previously overlooked biology into research, technology and clinical practice, we aim to redefine how precision radiotherapy is developed and applied.

Focus Areas

Precision radiotherapy

Translating biological discoveries into clinically meaningful treatment strategies.

Tumour sex chromosome biology

Investigating tumour sex chromosome state as a previously overlooked determinant of tumour biology and radiation response.

Artificial intelligence & computational oncology

Developing biologically informed AI and prediction frameworks for precision radiotherapy.

Clinical implementation

Integrating biological evidence into radiotherapy practice, guidelines and decision support.

Society, policy & responsible innovation

Exploring the broader implications of emerging biological discoveries through collaborations in health economics, ethics, law and the social sciences.

Flagship Publications (Selected)

  • Transforming biological understanding

    • Tumour sex chromosome state identifies aggressive cancer biology beyond recorded sex across human cancers (submitted)

    • Defective X-chromosome inactivation defines an immune-depleted poor-prognosis state in female cancers (submitted)

    • Loss of the Y chromosome defines a clinically aggressive radioresistant cancer state (submitted)

    International vision

    • DREAM: A joint physics–radiobiology vision for tumour response prediction (Radiotherapy and Oncology, 2024)

    • Targeting metabolic cell death pathways for radiation therapy (IJROBP, 2026)

    Translation into practice

    • ESTRO clinical guidelines

    • Vitamin D and radiotherapy

    • Re-irradiation biology

    • Precision radiotherapy implementation

Research platforms

  • Integrated laboratory and computational biology

  • Pan-cancer clinical datasets

  • AI-assisted biomarker discovery

  • Multidisciplinary translational research

  • International implementation networks

Scientific contributions

  • Bridging radiation biology with clinical oncology, medical physics and computational science.

  • Advancing tumour sex chromosome biology as a novel biological dimension of precision radiotherapy.

  • Developing multidisciplinary frameworks that accelerate translation from biological discovery to clinical implementation.

  • Expanding the contribution of radiation biology to emerging areas including artificial intelligence, implementation science and health policy.

Looking ahead

The future of precision radiotherapy will depend not only on technological innovation but also on a deeper understanding of tumour biology. Through our latest research programme, OSIRIS, we are investigating tumour sex chromosome state as a previously overlooked biological determinant of tumour behaviour and radiation response. By working across disciplines, we aim to translate this new understanding into improved prediction, more personalised treatment and a broader role for radiation biology in shaping the future of cancer care.

Get Involved

  • Our laboratory thrives on multidisciplinary collaboration. We welcome partnerships with clinicians, scientists, engineers, data scientists and researchers from across disciplines who share our ambition to uncover overlooked biology and translate new discoveries into better radiotherapy and cancer care.